CompletedNot Applicable

Genetics in the Effect of Caffeine on Fat Oxidation

Spain32 participantsStarted 2020-10-01

Plain-language summary

Genetic polymorphism on the effect of oral caffeine intake on fat oxidation during exercise has been studied in active and healthy population performing an incremental test on a cycle ergometer with 3-min stages at workloads from 30 to 70% of maximal oxygen uptake (VO2max). Participants performed this test after the ingestion of a) placebo; b) 3 mg/kg of caffeine; c) 6 mg/kg of caffeine. Fat oxidation rate during exercise was measured by indirect calorimetry. The influence of the CYP1A2 c.-163A\>C, GSTP c.313A\>G and PGC1a polymorphisms was evaluated to determine the effects on fat oxidation during exercise

Who can participate

Age range18 Years – 40 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: To be non-smokers. To have low caffeine intake (i.e., \< 50 mg of caffeine per day in the previous 2 months) To show no previous history of cardiopulmonary diseases or having suffered musculoskeletal injuries in the previous 6 months. Exclusion Criteria: To have VO2max values below 40 ml/kg/min To be sedentary

What they're measuring

Genotype frequency of CYP1A2 polymorphism

Timeframe: Baseline

Genotype frequency of GSTP polymorphism

Timeframe: Baseline

Genotype frequency of PGC1a polymorphisms

Timeframe: Baseline

Trial details

NCT IDNCT05975489

SponsorUniversidad Francisco de Vitoria

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2021-02-10

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