This study aims to identify and compare the effects of acute and chronic exercise interventions on cognition in middle-aged adults with cognitive complaints and a history of abuse or neglect in childhood. Each participant will be enrolled in the study for up to 78 days, in five parts following verification that the participant meets criteria to be included in the study: 1) initial assessment; 2) first acute exercise condition in lab, symptom measures, and neuropsychological testing; 3) second acute exercise condition in lab, symptom measures, and neuropsychological testing; and 4) 9-week exercise intervention or activity as usual outside of lab, with interview, symptom measures, and neuropsychological testing at three-week intervals.
Age range
40 Years – 60 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Change in performance (i.e., raw score of number of words recalled, in whole numbers) on the Loewenstein-Acevedo Scales for Semantic Interference and Learning (LASSI-L) from baseline will be compared within subjects.
Timeframe: one week before first acute exercise condition (baseline), after acute exercise condition on day 8, and after acute exercise condition on day 15.
Change in performance (i.e., raw score of total correct, in whole numbers) on the Wechsler Adult Intelligence Scale - Fourth Edition (WAIS-IV) Digit Span test from baseline will be compared within subjects.
Timeframe: one week before first acute exercise condition (baseline), after acute exercise condition on day 8, and after acute exercise condition on day 15
Change in performance (i.e., raw scores of time to complete task, in seconds) on the Trail Making Test (TMT) from baseline will be compared within subjects.
Timeframe: exercise condition on day 8, and after acute exercise condition on day 15
Change in performance (i.e., raw scores of time to complete task, in seconds) on the Symbol Digit Modalities Test (SDMT) from baseline will be compared within subjects.
Timeframe: one week before first acute exercise condition (baseline), after acute exercise condition on day 8, and after acute exercise condition on day 15
Change in performance (i.e., raw score of total correct, in whole numbers) on the Paced Auditory Serial Addition Test (PASAT) from baseline will be compared within subjects.
Timeframe: one week before first acute exercise condition (baseline), after acute exercise condition on day 8, and after acute exercise condition on day 15
Change in performance (i.e., raw scores of total words generated, in whole numbers) on the Controlled Oral Word Association Test (COWAT) from baseline will be compared within subjects.
Timeframe: one week before first acute exercise condition (baseline), after acute exercise condition on day 8, and after acute exercise condition on day 15
Change from baseline performance (i.e., raw score of number of words recalled, in whole numbers) on the Loewenstein-Acevedo Scales for Semantic Interference and Learning (LASSI-L) at 3 weeks post-chronic exercise intervention.
Timeframe: one week before first acute exercise condition (baseline) and after 3 weeks of the chronic exercise condition or activity as usual
Change from baseline performance (i.e., raw score of total correct, in whole numbers) on the Wechsler Adult Intelligence Scale - Fourth Edition (WAIS-IV) Digit Span test at 3 weeks post-chronic exercise intervention.
Timeframe: one week before first acute exercise condition (baseline) and after 3 weeks of the chronic exercise condition or activity as usual
Change from baseline performance (i.e., raw scores of time to complete task, in seconds) on the Trail Making Test (TMT) at 3 weeks post-chronic exercise intervention.
Timeframe: one week before first acute exercise condition (baseline) and after 3 weeks of the chronic exercise condition or activity as usual
Change from baseline performance (i.e., raw scores of time to complete task, in seconds) on the Symbol Digit Modalities Test (SDMT) at 3 weeks post-chronic exercise intervention.
Timeframe: one week before first acute exercise condition (baseline) and after 3 weeks of the chronic exercise condition or activity as usual
Change from baseline performance (i.e., raw score of total correct, in whole numbers) on the Paced Auditory Serial Addition Test (PASAT) at 3 weeks post-chronic exercise intervention.
Timeframe: one week before first acute exercise condition (baseline) and after 3 weeks of the chronic exercise condition or activity as usual
Change from baseline performance (i.e., raw scores of total words generated, in whole numbers) on the Controlled Oral Word Association Tet (COWAT) at 3 weeks post-chronic exercise intervention.
Timeframe: one week before first acute exercise condition (baseline) and after 3 weeks of the chronic exercise condition or activity as usual
Change from baseline performance (i.e., raw score of number of words recalled, in whole numbers) on the Loewenstein-Acevedo Scales for Semantic Interference and Learning (LASSI-L) at 6 weeks post-chronic exercise intervention.
Timeframe: one week before first acute exercise condition (baseline) and after 6 weeks of the chronic exercise condition or activity as usual
Change from baseline performance (i.e., raw score of total correct, in whole numbers) on the Wechsler Adult Intelligence Scale - Fourth Edition (WAIS-IV) Digit Span test at 6 weeks post-chronic exercise intervention.
Timeframe: one week before first acute exercise condition (baseline) and after 6 weeks of the chronic exercise condition or activity as usual
Change from baseline performance (i.e., raw scores of time to complete task, in seconds) on the Trail Making Test (TMT) at 6 weeks post-chronic exercise intervention.
Timeframe: one week before first acute exercise condition (baseline) and after 6 weeks of the chronic exercise condition or activity as usual
Change from baseline performance (i.e., raw scores of time to complete task, in seconds) on the Symbol Digit Modalities Test (SDMT) at 6 weeks post-chronic exercise intervention.
Timeframe: one week before first acute exercise condition (baseline) and after 6 weeks of the chronic exercise condition or activity as usual
Change from baseline performance (i.e., raw score of total correct, in whole numbers) on the Paced Auditory Serial Addition Test (PASAT) at 6 weeks post-chronic exercise intervention.
Timeframe: one week before first acute exercise condition (baseline) and after 6 weeks of the chronic exercise condition or activity as usual
Change from baseline performance (i.e., raw scores of total words generated, in whole numbers) on the Controlled Oral Word Association Tet (COWAT) at 6 weeks post-chronic exercise intervention.
Timeframe: one week before first acute exercise condition (baseline) and after 6 weeks of the chronic exercise condition or activity as usual
Change from baseline performance (i.e., raw score of number of words recalled, in whole numbers) on the Loewenstein-Acevedo Scales for Semantic Interference and Learning (LASSI-L) at 9 weeks post-chronic exercise intervention.
Timeframe: one week before first acute exercise condition (baseline) and after 9 weeks of the chronic exercise condition or activity as usual
Change from baseline performance (i.e., raw score of total correct, in whole numbers) on the Wechsler Adult Intelligence Scale - Fourth Edition (WAIS-IV) Digit Span test at 9 weeks post-chronic exercise intervention.
Timeframe: one week before first acute exercise condition (baseline) and after 9 weeks of the chronic exercise condition or activity as usual
Change from baseline performance (i.e., raw scores of time to complete task, in seconds) on the Trail Making Test (TMT) at 9 weeks post-chronic exercise intervention.
Timeframe: one week before first acute exercise condition (baseline) and after 9 weeks of the chronic exercise condition or activity as usual
Change from baseline performance (i.e., raw scores of time to complete task, in seconds) on the Symbol Digit Modalities Test (SDMT) at 9 weeks post-chronic exercise intervention.
Timeframe: one week before first acute exercise condition (baseline) and after 9 weeks of the chronic exercise condition or activity as usual
Change from baseline performance (i.e., raw score of total correct, in whole numbers) on the Paced Auditory Serial Addition Test (PASAT) at 9 weeks post-chronic exercise intervention.
Timeframe: one week before first acute exercise condition (baseline) and after 9 weeks of the chronic exercise condition or activity as usual
Change from baseline performance (i.e., raw scores of total words generated, in whole numbers) on the Controlled Oral Word Association Tet (COWAT) at 9 weeks post-chronic exercise intervention.
Timeframe: one week before first acute exercise condition (baseline) and after 9 weeks of the chronic exercise condition or activity as usual
Change from baseline cognitive complaints (i.e., total number of complaints) at 3 weeks post-chronic exercise intervention.
Timeframe: one week before first acute exercise condition (baseline) and after 3 weeks of the chronic exercise condition or activity as usual
Change from baseline cognitive complaints (i.e., total number of complaints) at 6 weeks post-chronic exercise intervention.
Timeframe: one week before first acute exercise condition (baseline) and after 6 weeks of the chronic exercise condition or activity as usual
Change from baseline cognitive complaints (i.e., total number of complaints) at 9 weeks post-chronic exercise intervention.
Timeframe: one week before first acute exercise condition (baseline) and after 9 weeks of the chronic exercise condition or activity as usual