Effects of Electronic Cigarette Flavors on Abuse Liability in Smokers (P3-Taste)

Inclusion Criteria: * healthy (determined by self-report) * at least 18 years old * willing to provide informed consent * able to attend the lab and use designated products according to the study protocol * smoke cigarettes at least 3 days per week, and on those days, at least one cigarette is smoked per day * positive urine cotinine test Exclusion Criteria: * Women who are breastfeeding or test positive for pregnancy (by urinalysis) at screening. * Individuals with the following self-reported current, diagnosed medical condition(s) will be excluded automatically: uncontrolled high blood pressure (via self-report or observed at screening; BP must be less than 160/100), heart-related conditions (e.g., recent heart attack/stroke, coronary heart disease), severe immune system disorders (e.g., HIV/AIDS, multiple sclerosis), respiratory disorders (e.g., COPD, asthma), kidney diseases, liver diseases (e.g., cirrhosis), or seizures. * Individuals with other self-reported current, diagnosed medical conditions (e.g., diabetes, thyroid disease, lyme disease) will be considered for exclusion after consultation with the PI and medical monitor. We ask a variety of questions about participants' medical conditions that are not necessarily exclusionary to be able to consult with the medical monitor about these conditions. Participants with any medical condition/medication that may affect participant safety, study outcomes, or biomarker data will be excluded based on these consultations. *…