CompletedNot Applicable

Effects of Sodium Chloride or Its Substitute Salt Potassium Chloride on Vascular Function

Germany45 participantsStarted 2023-08-09

Plain-language summary

This is a prospective, monocentric, randomized trial to investigate how sodium chloride or its substitute potassium chloride acutely affects vascular function by ingestion via a salted soup. Furthermore we want to get insights on the pathophysiology by analyzing metabolism and cell function in relation to vascular reaction.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * full-aged * signed informed consent * no dietary restrictions * access to retina for microvascular measurement Exclusion Criteria: * age \<18 y * no retinal access for microvascular measurement * known glaucoma * antibiotic therapy within the last 4 weeks * immunosuppressive Therapie within the last 4 weeks (e.g. glucocorticoids) * s.p. malignancy * unknown fever within the last 4 weeks * salt wasting syndroms (e.g. renal tubular acidosis, Diabetes insipidus) * chronic kidney disease stage 4-5 * known electrolyte disorder (e.g. hyperkalaemia, hypokalaemia, hypernatriaemia, hyponatriaema) * no or rejected informed consent

What they're measuring

Effect of a single oral high-sodium chloride load or a partial substitution by potassium chloride on retinal vessel diameter and the flicker-light-induced retinal vessel dilatation.

Timeframe: Baseline, 4 hours, 24 hours

Effect of a single oral high-sodium chloride load or a partial substitution by potassium chloride on hypoxia-induced dilatation of brachial artery.

Timeframe: Baseline, 4 hours, 24 hours

Trial details

NCT IDNCT05970601

SponsorProf. Dr. med. Johannes Stegbauer

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-03-22

View on ClinicalTrials.gov More Vascular Function trials