CompletedNot Applicable

Ventricular-Arterial Coupling: A Predictor of Post-Induction Hypotension

Vietnam405 participantsStarted 2023-07-03

Plain-language summary

Post-induction hypotension (PIH) is a common occurrence during the period from induction of general anesthesia to initiation of incision. PIH has been identified as an independent risk factor for postoperative major complications. Identifying high-risk patients for PIH could potentially help prevent its occurrence. Several risk factors associated with PIH have been identified, including patient conditions and use of specific anesthetic agents. Ventricular-arterial coupling (VAC) is evaluated using the ratio Ea/Ees and represents the interaction between the left ventricle (LV) and the arterial system. It reflects how changes in LV contractility (Ees) and changes in arterial load (Ea) work together to maintain optimal LV performance. A study aims to investigate the relationship between preoperative Ea/Ees ratio and the incidence of PIH (defined as MAP \< 65 mmHg).

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients ≥ 18 years old. * Patients with ASA (American Society of Anesthesiologists) physical status 1 - 4. * Elective surgery. * Preoperative transthoracic echocardiography was performed within 48 hours before surgery. The values of Ees and Ea were determined by the method of Chen. * Patients consented to participate in the study. * Patients scheduled for surgery undergoing standard general anesthesia (protocol: see below) with endotracheal intubation. * Patients were hemodynamically stable until the preoperative period. Exclusion Criteria: * Cardiac and obstetric surgery. * Allergy to any anesthetic drug. * Arrhythmia. * Severe valvular heart disease. * Severe pre-existing lung disease. * Mean pulmonary arterial pressure (PAPm ≥ 40 mmHg). * Anticipation of difficult airway management. * Hypotension occurs during the induction of anesthesia due to suspected anaphylaxis.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Prediction

Timeframe: from induction of anesthesia to incision initiation

Trial details

NCT IDNCT05969886

SponsorUniversity Medical Center Ho Chi Minh City (UMC)

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2024-11-20

View on ClinicalTrials.gov More Hypotension on Induction trials