Emotional Cognition: Establishing Constructs and Neural-Behavioral Mechanisms in Older Adults Wit… (NCT05966532) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Emotional Cognition: Establishing Constructs and Neural-Behavioral Mechanisms in Older Adults With Depression
United States276 participantsStarted 2023-12-11
Plain-language summary
This is a cross-sectional pilot study designed to establish hot and cold cognitive functions and underlying neurocircuitry in older adults with MDD. The investigators will study 120 participants aged 21-80 years old with MDD. All participants will undergo clinical and neurocognitive assessment, and Magnetoencephalography (MEG)/Magnetic resonance imaging (MRI) procedures at one time point. The investigators will also enroll 120 demographically matched comparable, never-depressed healthy participants (controls) to establish cognitive benchmarks. Healthy controls will complete clinical and neurocognitive measures at one time point. To attain a balanced sample of adults across the lifespan, the investigators will enroll participants such that each age epoch (e.g., 21-30, 31-40, etc.) has a total of ten subjects (n=10) in both the healthy control cohort and depressed cohort.
Who can participate
Age range21 Years – 80 Years
SexALL
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Inclusion criteria
✓. Male and female participants
✓. Age between 21-80 years old
✓. DSM-5 diagnosis of major depressive disorder (MDD) based on Mini Neuropsychiatric Interview
✓. Inventory of Depressive Symptomatology-Clinician Rated version (IDS-C) total score \> 14
✓. Able to read, write, and comprehend English
✓. Provide informed consent; willing to comply with study protocol
Exclusion criteria
✕. History of bipolar disorder, schizophrenia, or schizoaffective disorder
✕. Presence of psychotic features
✕. Lifetime central nervous system (CNS) disease (including head injury with loss of consciousness \> 5 minutes)
✕. History of neurodevelopmental disorder (e.g., Autism spectrum disorder)
. History of medical conditions that can affect neurocognitive function as well as be confounded with age (e.g., thyroid disease, endocrine illnesses)
✕. Women who are pregnant
✕. Current use of medications with known impacts on neurocognitive function (e.g., acetylcholinesterase inhibitors, amphetamine, methylphenidate, vortioxetine, sedatives)
✕. Alcohol/substance use disorder within past 3 months