The Efficacy of Laser in Root Canal Disinfection (NCT05964686) | Clinical Trial Compass
CompletedPhase 2
The Efficacy of Laser in Root Canal Disinfection
Egypt30 participantsStarted 2022-01-01
Plain-language summary
The aim of this study is to assess in vivo the efficacy of Er,Cr:YSGG/diode laser and Diode/EDTA on bacterial count in root canal treatment in an evidence-based clinical trial. The null hypothesis being tested is that there is no difference in total bacterial count reduction between conventional irrigation and the two types of lasers used.
Thirty patients are equally divided into 3 separate groups :
* Group A (Conventional): 2.5% NaOCL and 17% EDTA.
* Group B(Dual): saline along with Er,Cr:YSGG laser and diode laser combination
* Group C(Combined): saline along with 17% EDTA and diode laser combination Microbiological analysis will be done for both aerobic and anaerobic bacteria using Colony forming units. All data will be collected, tabulated, summarized, and statistically analyzed.
Who can participate
Age range
18 Years – 35 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* • Patients who are medically free.
* Patient's age between 18-35 years.
* One single rooted maxillary anterior tooth with necrotic pulp and asymptomatic apical periodontitis requiring root canal treatment.
* Patients complaining of no pain and without fistulous tract.
* Periapical lesion with a periapical index score of 3 or 4 (Ørstavik, et al. (1986)108
* Closed apex.
* Acceptance to participate in the study.
Exclusion Criteria:
* Patients suffering from any systemic disease.
* Patients who had received antibiotics during the last month.
* Patients taking analgesics 12 hours before interventions.
* Patients with history of tobacco usage
* Teeth with vital pulp, calcified canals, and immature or incompletely formed apices.
* Teeth with previous endodontic treatment.
* Non restorable teeth where rubber dam could not be applied.
* Teeth with periodontal pocket more than 3 mm.
* Teeth with greater than grade 1 mobility.
* Teeth with swelling/sinus tract.
* Technical difficulties in the course of root canal treatment for example:
* A tooth with curved roots
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Quantitative microbiological analysis
Timeframe: baseline (S1): sample will be obtained before canal disinfection. post operative (S2): sample will be obtained after canal disinfection in a single visit]