RecruitingPhase 2

CAlcium and VAsopressin Following Injury Early Resuscitation (CAVALIER) Trial

United States1,050 participantsStarted 2024-06-30

Plain-language summary

The CAlcium and VAsopressin following Injury Early Resuscitation (CAVALIER) Trial is a proposed 4 year, double-blind, mutli-center, prehospital and early in hospital phase randomized trial designed to determine the efficacy and safety of prehospital calcium and early in hospital vasopressin in patients at risk of hemorrhagic shock.

Who can participate

Age range18 Years – 90 Years

SexALL

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Inclusion criteria

✓.Blood/blood component transfusion initiated in prehospital setting or deemed clinically indicated within 60 minutes of arrival at the enrolling trauma center

Exclusion criteria

✕. Wearing NO CAVALIER opt-out bracelet
✕. Age \> 90 or \< 18 years of age
✕. Isolated fall from standing injury mechanism
✕. Known prisoner
✕. Known pregnancy
✕. Traumatic arrest with \> 5 minutes of CPR without return of vital signs
✕. Brain matter exposed or penetrating brain injury
✕. Isolated drowning or hanging victims

What they're measuring

Number of participants with 30-day mortality

Timeframe: from randomization to death or 30 days, whichever comes first

Trial details

NCT IDNCT05958342

SponsorJason Sperry

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-03

Contact for this trial

Jason Sperry, MD

4128028270 sperryjl@upmc.edu

View on ClinicalTrials.gov More Trauma trials