UnknownNot Applicable

Effects of Remote Ischemic Preconditioning on Peripheral Blood Biomarkers in Healthy Adults (EMINENT)

China60 participantsStarted 2024-06-27

Plain-language summary

The aim of this study is to investigate the effects of remote ischaemic preconditioning on the peripheral blood characteristics of healthy adults and to explore the possible mechanisms for improving ischaemia/reperfusion injury and its protective effects on the cardiovascular system.

Who can participate

Age range

18 Years – 45 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Aged 18 to 45 years; * Be in good health; * Consent to participate in the clinical trial and sign the informed consent form. Exclusion Criteria: * Abnormal results in biochemical checks and physiological indicators. * Cardiovascular and cerebrovascular diseases: hypertension, coronary heart disease, congenital heart disease, cerebrovascular alterations, etc. * Endocrine diseases: diabetes, thyroid disorders, etc. * Hematologic diseases: anemia, paroxysmal hemoglobinuria, primary thrombocytosis, etc. * Infectious diseases: hepatitis B, hepatitis C, syphilis, etc. * Cancer. * Neurological and psychiatric disorders. * Vascular diseases: peripheral vascular disease, Raynaud's syndrome, thromboembolic diseases. * Major trauma or surgery within the last six months. * Pregnant or breastfeeding women. * Upper limbs unsuitable for compression treatment: history of upper limb surgery, presence of tissue damage and limb deformity, and concomitant hemorrhagic diseases. * Recent circumstances that may affect results: blood donors within the last month, any medication taken within the last month, fever within the last week, women within their menstrual cycle or within 7 days before the start of menstruation. * Patients who refuse to sign the informed consent form for participation in this study.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Comparison of changes in various biomarkers between intermediate and intense training group

Timeframe: Baseline (before training), the end of the training day (7th day from the start of training), 7th day after the end of training

Change of peripheral blood characteristics

Timeframe: Baseline (before training), the end of the training day (7th day from the start of training), 7th day after the end of training

Change of gut microbiome components at different remote ischemic preconditioning training time points

Timeframe: Baseline (before training), the end of the training day (7th day from the start of training), 7th day after the end of training

Trial details

NCT IDNCT05957523

SponsorFirst Affiliated Hospital Xi'an Jiaotong University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-12-12

Contact for this trial

Guoliang Li

00-86-029-85323805 liguoliang_med@163.com

View on ClinicalTrials.gov More Ischemic Preconditioning trials

Who can participate

Age range

18 Years – 45 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Comparison of changes in various biomarkers between intermediate and intense training group

Timeframe: Baseline (before training), the end of the training day (7th day from the start of training), 7th day after the end of training

Change of peripheral blood characteristics

Timeframe: Baseline (before training), the end of the training day (7th day from the start of training), 7th day after the end of training

Change of gut microbiome components at different remote ischemic preconditioning training time points

Timeframe: Baseline (before training), the end of the training day (7th day from the start of training), 7th day after the end of training