The Hypoalgesic Effects of BFR Training in Nonspecific Shoulder Pain.

Adults presenting with nonspecific shoulder pain will be recruited using the following eligibility criteria: Inclusion Criteria: * Age \>18≤40 years considering that the prevalence for degenerative rotator cuff tendinopathy increases from the age of 40 and above * Shoulder pain intensity \> 4/10 NPRS when performing active glenohumeral abduction and/or isometric resistance to glenohumeral external rotation from 0° of abduction. * Duration of symptoms \> 3 weeks (to avoid an inflammatory clinical picture). Exclusion Criteria: * Positive drop arm test (important indication for rotator cuff tear) * Cervical radiculopathy having a positive specific spurling test or neurological symptoms in the upper limb * Passive deficit in range of motion (ROM) \> 2 levels of motion, where according to the literature it is an indication of frozen shoulder * Body Mass Index (BMI) \> 28 * Previous shoulder surgery * Previous humerus fracture * Cancer * Rheumatic diseases * Systemic pathologies (e.g. diabetes, rheumatism, fibromyalgia) * History of previous neurological diseases * History of thrombosis * Cardiovascular pathologies * Neurological diseases * Long-term use of corticosteroids * Injury or surgery \< 1 month related to the shoulder girdle * Hypertension (\> 140/90mmHg) * Anti-inflammatory treatment in the last 2 weeks * Injectable therapy (last 3 months) * Previous experience/knowledge of the BFR technique * Inability to write and read Greek