Effect of Early Extracorporeal Diaphragm Pacing Combined With Tilt Table in Ventilated Patients.

Inclusion Criteria: * Duration of mechanical ventilation prior to enrollment≤ 72 hours. * Expected duration of mechanical ventilation≥72 hours. * Participants (or their legal representatives) have signed informed consent. Exclusion Criteria: * Pregnancy or breast-feeding. * Prone ventilation or current extracorporeal membrane oxygenation. * Hemodynamic instability: mean arterial pressure is less than 65 millimeters of mercury (mmHg) or higher than 85 millimeters of mercury (mmHg), heart rate \> 150 beats / minute, intravenous use of larger doses of vasopressors (such as dopamine \> 10 mg/ (kg· min) or norepinephrine/epinephrine \>0.1 mg/ (kg· min)) or aortic balloon counter pulsation; respiratory rate\< 5 breaths per minute; Oxygen saturation\< 88%. * New-onset myocardial ischemia. * Unstable cervical spine fracture and spinal cord injury. * Deterioration of neurological function, requiring intracranial pressure monitoring and ventricular drainage, or active control of intracranial hypertension. * Current neuromuscular block treatment or pre-existing neuromuscular disease or neuromuscular junction disease affecting respiratory muscle (such as myasthenia gravis, Guillain-Barré syndrome, etc.). * There are contraindications to diaphragmatic pacing (local skin, tissue incompleteness or infection, chest X-ray examination shows pneumothorax or pleural effusion accounting for 1/3 of bilateral chest cavity). * Body mass index (BMI) ⩾40 kg/m2. * Known / suspected phrenic nerve pal…