CompletedPhase 2/3

Progesterone Primed Protocol Versus GnRH Antagonist in With PCO Undergoing ICSI

Egypt200 participantsStarted 2024-01-01

Plain-language summary

To compare the effectiveness and safety of Progesterone Primed Ovarian Stimulation protocol (PPOS) using Dydrogestrone vs GnRH Antagonist Protocol in patients with expected high ovarian response undergoing ICSI cycle

Who can participate

Age range20 Years – 40 Years

SexFEMALE

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Inclusion criteria

✓. undergoing trial of ICSI.
✓. BMI ≤ 30
✓. AMH ≥3.5
✓. AFC ≥ 20

Exclusion criteria

✕. Any known contraindications to the approved fertility drugs.
✕. Severe endometriosis.
✕. Uterine malformations or abnormal uterine cavity.
✕. Uncontrolled endocrinopathies:DM,hyperthyroidism, hypothyroidism
✕. Severe male factor
✕. History of recurrent ICSI failure or recurrent miscarriage

What they're measuring

oocytes retrieved

Timeframe: 1 month of induction for ICSI trial

Trial details

NCT IDNCT05951400

SponsorBeni-Suef University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-03-30

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