Effects of Exercise Training and Ketone Ester on Muscle Strength and Cardiovascular Response in P… (NCT05948956) | Clinical Trial Compass
CompletedNot Applicable
Effects of Exercise Training and Ketone Ester on Muscle Strength and Cardiovascular Response in Parkinson's Disease
United States19 participantsStarted 2023-07-28
Plain-language summary
The main purpose of this study is to assess changes in exercise capacity in people with Parkinson's disease before and after an exercise training program with ketone ester supplementation.
Who can participate
Age range45 Years
SexALL
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Inclusion Criteria:
* Diagnosis of Parkinson's Disease
Exclusion Criteria:
* Any recent changes in EKG, history of myocardial infarction or other cardiac event or other cardiac contraindications to exercise
* Inability to use a step, stand, walk, or use a stationary cycle ergometer
* History of symptoms in exercise that preclude safe and comfortable participation, such as dizziness and lightheadedness, orthostasis, severe symptomatic leg or back musculoskeletal pain, painful neuropathy, significant ankle edema or medication side effects
* History of symptomatic cardiovascular or pulmonary disease interfering with exercise
* History of active rheumatoid arthritis
* History of uncontrolled chronic pain syndrome
* Any other history of medical or psychiatric comorbidity precluding safe participation in the project
* Poorly controlled diabetes
* Pregnancy or breastfeeding
* Clinically significant dementia
* Any contraindications to MRI (metal implants, severe claustrophobia, inability to lie still for 1 hour, etc.)
What they're measuring
1
Change in Duration of 80 Rpm Endurance Test
Timeframe: After approximately 2 weeks of intervention
2
Change in Oxygen Uptake (VO2 Max)
Timeframe: After approximately 2 weeks of intervention