Comparison of Plasma Neutrophil Gelatinase-Associated Lipocalin (pNGAL) Level in De-resuscitation… (NCT05939245) | Clinical Trial Compass
CompletedNot Applicable
Comparison of Plasma Neutrophil Gelatinase-Associated Lipocalin (pNGAL) Level in De-resuscitation With Furosemide Group and Control Group
Indonesia40 participantsStarted 2023-07-24
Plain-language summary
The impact of early de-resuscitation with furosemide on patients with sepsis-related acute kidney injury using pNGAL as the parameter of acute kidney injury.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Sepsis patients with a cumulative balance of \>1500 mL/day and urine output \<0.8 cc/kg/hour.
Exclusion Criteria:
* Has undergone a kidney transplant procedure.
* End-stage chronic kidney failure.
* History of heart valve abnormalities.
* Congenital heart disease.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial used a blood marker called pNGAL to track kidney injury in sepsis patients — is checking my pNGAL level something that could help monitor how my kidneys are responding to treatment right now?
2The trial compared using furosemide to remove excess fluid versus a control group in patients with sepsis-related acute kidney injury — based on the results, does my doctor think active fluid removal with a diuretic like furosemide would be appropriate for my situation?
3Since this trial is completed, has my doctor seen or can they access the findings, and do the results change how they'd approach managing fluid balance in my care?
4This study was labeled Phase NA, meaning it was more of an observational or measurement study rather than a drug efficacy trial — does that mean the findings are more about monitoring tools than proving a specific treatment works, and how should I weigh that?
5Are there other completed or ongoing studies on kidney injury biomarkers in sepsis that my doctor thinks are more directly relevant to my treatment decisions right now?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.