CompletedNot Applicable

Effect of Urine-guided Hydration on Acute Kidney Injury After CRS-HIPEC

China168 participantsStarted 2023-07-24

Plain-language summary

Acute renal injury (AKI) is a common complication after cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC), and is associated with worse outcomes. Available evidences show that maintaining intraoperative urine output ≥ 200 ml/h by fluid and furosemide administration may reduce the incidence of AKI in patients undergoing cardiopulmonary bypass. The investigators hypothesize that, for patients undergoing CRS-HIPEC, intraoperative urine-volume guided hydration may also reduce the incidence of postoperative AKI.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age ≥18 years; * Diagnosed as pseudomyxoma peritonei, scheduled for cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy under general anesthesia; * At least 14 days since the last treatment of chemotherapy, radiotherapy, or immunotherapy; * Consent to participate in this study. Exclusion Criteria: * Persistent preoperative atrial fibrillation, or new-onset cardiovascular event (acute coronary syndrome, stroke, or congestive heart failure) in the past 3 months; * Requirement of vasopressors to maintain blood pressure before surgery; * Known furosemide hypersensitivity; * Chronic kidney disease stage 5 or requirement of renal replacement therapy; * Other conditions that are considered unsuitable for the study participation.

What they're measuring

Incidence of acute kidney injury (AKI) within 7 days after surgery

Timeframe: Up to 7 days after surgery

Trial details

NCT IDNCT05939193

SponsorPeking University First Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-07-19