Examining the Role of Female Endogenous Sex Hormones in Eccentric Exercise (NCT05934708) | Clinical Trial Compass
RecruitingNot Applicable
Examining the Role of Female Endogenous Sex Hormones in Eccentric Exercise
United States30 participantsStarted 2025-03-07
Plain-language summary
The fluctuating concentrations of female sex hormones, namely estrogen and progesterone may have an effect on the ability of the tissue to withstand challenging exercise conditions, such as eccentric exercise. These sex hormones have also been purported to influence the perceived difficulty of exercise. This study aims to uncover how the different estrogen and progesterone concentrations present throughout the menstrual cycle effect perceived readiness to perform, perceptions of difficulty, and different recovery metrics.
Who can participate
Age range
18 Years – 35 Years
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* 18-35 years of age
* BMI of 18.5-29.9 as a BMI below or above these cut points results in highly varied menstrual cycle lengths \[15\]
* Not taking contraception or other types of medication that could influence reproductive status
* Regular menstruation
* Non-pregnant
* Medically free from chronic diseases
* Novel to downhill running
* Weight greater than or equal to 110 lbs
* Not taking exogenous hormones
* Not suffering from known gynecological disease (i.e., PCOS, endometriosis, etc.) that may influence menstrual cycle regularity
Exclusion Criteria:
* Amenorrhea or oligomenorrhea
* Perimenopausal or menopausal
* Recreational or professional trail or downhill runner
* On a form of contraception
* Cardiac disability
* Pacemaker
* Arterial disease
* Uncontrolled hemorrhage
* Blood clots
* Pregnant or trying to become pregnant
* Cancerous lesions
* Sensory or mental impairment
* Unstable fractures
* Weight less than 110 lbs
* Suffering from gynecological disease (i.e., PCOS, endometriosis, etc.) that may influence menstrual cycle regularity
* Taking exogenous hormones
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Preparedness to perform
Timeframe: Pre exercise
2
Rating of difficulty
Timeframe: 30 minutes
3
Inflammatory markers
Timeframe: Change over time (pre/post, 24 hour, 48 hour)
4
Counter movement jump height
Timeframe: Change over time (pre/post, 24 hour, 48 hour)
5
Passive Delayed Onset Muscle Soreness (DOMS)
Timeframe: Change over time (pre/post, 24 hour, 48 hour)
6
Active Delayed Onset Muscle Soreness (DOMS)
Timeframe: Change over time (pre/post, 24 hour, 48 hour)