There is an increasing focus on the need to optimise nutrition, lifestyle and metabolism of parents before and during pregnancy and of the infant after birth, but as yet there is limited understanding of the specific influences and of the underlying mechanisms. This study is a follow up of children from the NiPPeR trial of a nutritional drink enriched with micronutrients, myo-inositol and probiotics taken preconception and during pregnancy. In this setting we will examine the influence of parental nutrition, lifestyle and metabolism before and during pregnancy on child growth, development and well-being; ascertaining growth, adiposity, metabolism, neurobehavioural and health outcomes in the children, and characterising the underlying mechanisms. The data collected will allow identification of the contributions of parental and offspring characteristics, nutritional, lifestyle and medical factors, social and economic status, ethnicity, genetics, metabolism and microbes to promoting healthy growth, body composition and wellbeing in the children.
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Child Body Mass Index (kg/m2), derived from weight and height
Timeframe: Up to age 8 years, from periconception to age 8 years
Intellectual function (WASI-II IQ [4 sub-test scores], higher score is a higher IQ)
Timeframe: Up to age 8 years, from periconception to age 8 years
Child insulin resistance (HOMA2-IR [no units], higher value is greater insulin resistance)
Timeframe: Up to age 8 years, from periconception to age 8 years
Dimensional Change Card Sort Test (raw & T-scores)
Timeframe: Up to age 8 years, from periconception to age 8 years
Flanker Inhibitory Control & Attention Test (raw & T-scores)
Timeframe: Up to age 8 years, from periconception to age 8 years
Strengths & Difficulties Questionnaire score (no units)
Timeframe: Up to age 8 years, from periconception to age 8 years
Child Behaviour Check List score (no units)
Timeframe: Up to age 8 years, from periconception to age 8 years