The present protocol aims to understand and establish whether there is a causal link between adipose tissue metabolic remodeling and Type 2 Diabetes (T2D) remission after bariatric surgery. All participants will have a bariatric surgery, divided in 2 groups: with or without T2D.
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Change in white adipose tissue dietary fatty acid (DFA) trapping and partitioning
Timeframe: measured after liquid meal at Baseline (A0 +A1), at Day 12 (B0) and at Week 52 (C0)
Change in lean organ (liver, heart and muscle) DFA uptake and partitioning
Timeframe: measured after liquid meal at Baseline (A0 +A1), at Day 12 (B0) and at Week 52 (C0)
Change in liver non-esterified fatty acid (NEFA) uptake, oxidation, esterification and secretion into very low-density lipoprotein (VLDL).
Timeframe: measured before and after liquid meal at Baseline (A0), at Day 12 (B0) and at Week 52 (C0)
Change in Endogenous Glucose production and meal glucose systemic flux
Timeframe: measured before and after liquid meal at Baseline (A0 +A1), at Day 12 (B0) and at Week 52 (C0)
Change in cardiac non-esterified fatty acid (NEFA) uptake, oxidation and esterification
Timeframe: measured before and after liquid meal at Baseline (A0), at Day 12 (B0) and at Week 52 (C0)