UnknownNot Applicable

Endotoxinemia and Vasoplegia Following Cardiothoracic Surgery With Cardiopulmonary Bypass (CPB)

Germany200 participantsStarted 2023-10-02

Plain-language summary

This observational study investigates the effect of endotoxinemia on the postoperative incidence of vasoplegia or vasoplegic shock in patients undergoing cardiac surgery with the use of cardiopulmonary bypass.

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. adult patients undergoing cardiac surgery requiring CPB
✓. written informed consent

Exclusion criteria

✕. emergency surgery in the context of acute coronary syndrome
✕. patients with chronic inflammatory diseases of the gut
✕. patients receiving immunosuppressive drugs
✕. patients with infectious endocarditis
✕. patients with sepsis
✕. patients with chronic kidney disease with estimated glomerular filtration rate (eGFR) \<20 ml/min/1,73m²
✕. persons with any kind of dependency on the investigator or employed by the institution responsible or investigator
✕. persons held in an institution by legal of official order -

What they're measuring

Norepinephrine equivalent dose (NED)

Timeframe: within 24 hours following induction of general anesthesia

Trial details

NCT IDNCT05925348

SponsorUniversität Münster

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2024-12

Contact for this trial

Sadjadi, MD

+49-251-8347255 aki@anit.uni-muenster.de

View on ClinicalTrials.gov More Vasoplegia trials