Active — Not RecruitingPhase 1

Hyperbaric Oxygen Treatment (HBOT) During Methadone Tapering

United States36 participantsStarted 2023-12-04

Plain-language summary

The aims of this study are to 1) explore the efficacy of hyperbaric oxygen therapy (HBOT) applied at two different pressures compared to sham treatment in relieving signs and symptoms (both physical and psychological) of opioid withdrawal in human subjects associated with methadone dose reductions; and 2): explore whether HBOT can increase the odds of successful methadone dose reduction in patients who are interested in tapering their opioid dose. The investigators aim to explore, through qualitative methods, individual's experiences with treatment for opioid use disorder (OUD).

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Enrollment in a supervised opioid treatment program at the Spokane Regional Health District * Age greater than 18 years * Ability to read, speak, and write English * Ability to provide written informed consent. Exclusion Criteria: * Pregnancy * Any other medical or psychiatric condition that the PI, Co-PI (physician of record) or the Spokane Hyperbaric Center medical director determine might compromise safe study participation in the HBOT clinic (including but not limited to active psychosis, history of frequent psychiatric hospitalizations, severe anxiety with claustrophobia, aggression) * Upper respiratory infection * Emphysema * Air cysts in the lung * History of thoracic or ear surgery * Taking the medication Antabuse for alcohol addiction * High fever.

What they're measuring

Change in Adjective Rating Scale of Withdrawal (ARSW)

Timeframe: Subjects will be assessed for withdrawal signs and symptoms at week 1 and compared with the end of week 4.

Trial details

NCT IDNCT05924022

SponsorWashington State University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-09-30