CompletedNot Applicable

Clinical and Histological Analysis of Human Gingival Phenotypes

Greece45 participantsStarted 2020-03-05

Plain-language summary

The goal of this observational study is to compare the composition of the human gingiva in different gingival phenotypes. The main questions to answer are: * Is there any difference in the cellular composition of the gingiva between thin and thick gingival phenotype? * Is there any difference in the molecular composition of the gingiva between thin and thick gingival phenotype? The participants were divided in two groups (thin and thick phenotype) and a biopsy of healthy gingiva was obtained from each one them. The biopsies were analyzed histologically and the collected data will be analyzed statistically in order to identify possible differences between the gingival phenotypes.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Healthy adults Exclusion Criteria: * Attachment loss or Probing depths greater than 2 millimeters at the maxillary central incisors * Altered passive eruption of the maxillary incisors * Previous surgery or orthodontic treatment in the anterior maxilla * Medical conditions or medication affecting soft tissue metabolism * Tooth crowding or abnormal angulation or abrasion of the maxillary incisors * Restorations at the buccal surface of the maxillary central incisors * Smoking * Pregnancy or lactation

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Cell density

Timeframe: Baseline

Trial details

NCT IDNCT05923671

SponsorAristotle University Of Thessaloniki

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2022-12-01

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