CompletedNot Applicable

The Effect of Probiotics on Gingivitis: Part 2

Russia60 participantsStarted 2023-04-24

Plain-language summary

The aim of the study is to assess the effect of oral probiotics containing Streptococcus salivarius M18 on gingivitis and oral hygiene in young adults.

Who can participate

Age range18 Years – 25 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Aged between 18-25 years * Permanent bite; * Presence of more than 20 teeth; * Absence of systemic and chronic diseases; * The diagnosis of gingivitis stated clinically. Exclusion Criteria: * Presence of mild, moderate or severe chronic periodontitis; * Refusal to sign informed consent; * Taking supplements and medication containing probiotics or prebiotics 1 months before the study; * Taking antibiotics (within 3 months before the study); * Allergy to the components of the drugs used in the study; * Presence of immunodeficiency, taking immunosuppressants. * Use of other hygiene products, immunostimulants and antibacterials, probiotics, prebiotics during the study; * Refusal to take a given medication; * Failure to attend check-ups.

What they're measuring

Evaluation of gingival inflammation using Gingival Index (GI) by H. Loe and J. Silness

Timeframe: 4 weeks after the baseline

Evaluation of gingival inflammation using Gingival Index (GI) by H. Loe and J. Silness

Timeframe: 8 weeks after the baseline

Evaluation of gingival inflammation using Gingival Index (GI) by H. Loe and J. Silness

Timeframe: 12 weeks after the baseline

Evaluation of gingival inflammation using Gingival Index (GI) by H. Loe and J. Silness

Timeframe: 16 weeks after the baseline

Evaluation of gingival inflammation using Gingival bleeding index (GBI) by J. Ainamo and I. Bay, 1975

Timeframe: 4 weeks after the baseline

Evaluation of gingival inflammation using Gingival bleeding index (GBI) by J. Ainamo and I. Bay, 1975

Timeframe: 8 weeks after the baseline

Evaluation of gingival inflammation using Gingival bleeding index (GBI) by J. Ainamo and I. Bay, 1975

Timeframe: 12 weeks after the baseline

Trial details

NCT IDNCT05919134

SponsorI.M. Sechenov First Moscow State Medical University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-09-20

View on ClinicalTrials.gov More Gingivitis; Chronic trials

Who can participate

Age range18 Years – 25 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Evaluation of gingival inflammation using Gingival Index (GI) by H. Loe and J. Silness

Timeframe: 4 weeks after the baseline

Evaluation of gingival inflammation using Gingival Index (GI) by H. Loe and J. Silness

Timeframe: 8 weeks after the baseline

Evaluation of gingival inflammation using Gingival Index (GI) by H. Loe and J. Silness

Timeframe: 12 weeks after the baseline

Evaluation of gingival inflammation using Gingival Index (GI) by H. Loe and J. Silness

Timeframe: 16 weeks after the baseline

Evaluation of gingival inflammation using Gingival bleeding index (GBI) by J. Ainamo and I. Bay, 1975

Timeframe: 4 weeks after the baseline

Evaluation of gingival inflammation using Gingival bleeding index (GBI) by J. Ainamo and I. Bay, 1975

Timeframe: 8 weeks after the baseline

Evaluation of gingival inflammation using Gingival bleeding index (GBI) by J. Ainamo and I. Bay, 1975

Timeframe: 12 weeks after the baseline