RecruitingNot Applicable

Peer-led Implementation of TB-HIV Education and Adherence Counseling in Uganda

Uganda1,920 participantsStarted 2026-03-16

Plain-language summary

This cluster-randomized trial in Uganda will evaluate the effectiveness and implementation of a novel, peer-led TB education and counseling strategy to improve outcomes among persons with tuberculosis (TB) with and without HIV/AIDS and assess the social-behavioral mechanisms underlying the observed treatment effects.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age ≥18 years * Registered as a new, relapse, treatment failure, or previously lost-to-follow-up * TB case according to the on-site NTP TB Treatment Register * Screened and invited to participate within 30 days of TB treatment initiation Exclusion Criteria: * Diagnosed with possible or confirmed drug-resistant TB * Transferring TB care into the clinic from an off-site facility * Residing \>40 km from the enrolling clinic * Lacking mental capacity to provide informed consent

What they're measuring

Effectiveness: TB Treatment Success

Timeframe: Up to 12 months after TB treatment initiation

Effectiveness: Antiretroviral Therapy (ART) Retention

Timeframe: At month 6 after ART initiation (+/- 30 days)

Trial details

NCT IDNCT05917210

SponsorYale University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2028-04-16

Contact for this trial

J. Lucian Davis, MD, MAS

203-785-2912 Lucian.Davis@yale.edu

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