Biomarkers Of Lung InVolvement In ASMD

Inclusion Criteria: Patients: * The patient has a biochemical and genetically confirmed diagnosis of the chronic visceral subtype of ASMD * The patient is willing and able to provide written informed consent prior to the study-related procedure. * The patient is ≥ 12 years of age Healthy controls: * The individual is willing and able to provide written informed consent prior to the study-related procedure * The individual is ≥ 16 years of age * General good health as determined by medical history Exclusion Criteria: Patients: * Inability to adhere to the study protocol * When a patient is not able to complete a spirometry test, the eNose sample will not be collected. Healthy controls: * Medical history of (systemic) disease for which medication was necessary * Inability to adhere to the study protocol