Patients with Postural Orthostatic Tachycardia Syndrome (POTS) and Post-Acute Sequelae of COVID (PASC, or "Long COVID") experience cognitive dysfunction. The investigators will test the hypothesis that 999 mL of IV saline will improve cognitive function in patients with POTS and Long COVID compared to placebo (50 mL of saline).
Who can participate
Age range18 Years – 60 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients with diagnosis of Long COVID
* SARS-COV2 test positive
* Symptoms \> 12 weeks post COVID
* Subjective complaint of 'brain fog" or cognitive dysfunction
* Patients with diagnosis of Postural Orthostatic Syndrome (POTS) from the Calgary Autonomic Investigation and Management Clinic
* Subjective complaint of 'brain fog" or cognitive impairment
* Healthy participants
* Without POTS or "brain fog"
* Age 18 to 60 years
* Female and Male
* Able to give an informed consent
Exclusion Criteria:
* Patients with overt causes for POTS (e.g., dehydration, prolonged bed rest)
* An inability to safely withdraw from medicine(s) that could make test interpretation difficult and impossible.
* Other factors which are in the investigator's opinion would prevent the participant from completing the protocol, including poor compliance during previous studies or an unpredictable schedule.
* Unable to give an informed consent.