Not Yet RecruitingNot Applicable

Evaluation of Intestinal Microbiota Implication in Ruptured Intracranial Aneurysm

50 participantsStarted 2024-08-31

Plain-language summary

The physiopathology of intracranial aneurysm from initiation to ruptured is incompletely understood but included inflammation. The microbiota is known to interact with brain and can promote inflammation. The objective of this study is to describe microbiota with taxonomic and metabolomic analysis. A comparison between ruptured and unruptured intracranial aneurysm will be performed. The study hypothesis is that microbiota is different between ruptured and unruptured patient.

Who can participate

Age range18 Years

SexALL

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Inclusion Criteria: * one or more intracranial sacciform aneurysm ruptured or not in function of the inclusion group Exclusion Criteria: * Transient modification of microbiota: Antibiotherapy in the last 3 months, pre or probiotic in the last month, gastrostomy, ileostomy, bariatric surgery, digestive tract resection, gastro-duodenal ulcer surgery or during the last month, chronic inflammatory disease of the digestive tract (like Crohn), BMI for more than 30, Very restrictive diet (like vegan * Specific pathologies increasing the incidence of aneurysm ( kidney autosomic dominant polycystosis, Type 1 neurofibromatosis, Rendu-Osler, MArfan * Participation to a study with the objective of microbiota modification

What they're measuring

Taxonomic faecal microbiota description

Timeframe: The faecal samples will be taken at 3 days+/-2 after the ruptured and during the arteriography for the unruptured group within 3 months after inclusion

Trial details

NCT IDNCT05914636

SponsorHospices Civils de Lyon

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-08-31

Contact for this trial

Dumot Chloé, Dr PhD

+334 72355839 chloe.dumot@chu-lyon.fr