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Nutrients-fortified Egg Consumption on Eczema Condition in Individuals With Eczema

Singapore41 participantsStarted 2023-03-06

Plain-language summary

The study aims to assess the effects of daily consumption of nutrients-fortified eggs on eczema condition in individuals with eczema. It is hypothesised that daily consumption of nutrients-fortified egg, which is rich in antioxidants, will improve eczema conditions in individuals with eczema as compared to consumption of regular eggs.

Who can participate

Age range21 Years – 59 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. English-literate and able to give informed consent in English
✓. Male and female subjects, aged between 21 and 59 inclusive
✓. Healthy individuals with no comorbidities or on regular medication
✓. BMI between 18.5-25 kg/m2
✓. Mild to moderate severity of eczema, which will also be determined using our questionnaires during screening visit

Exclusion criteria

✕. Significant change in body weight (3 kg or more) in the past 3 months
✕. Significant exercise pattern over the past 3 months defined as high-intensity exercise of more than 3 hours per week
✕. Known food allergy to eggs
✕. Taking dietary supplements which may impact the study results
✕. Had been diagnosed or with a history of gastrointestinal disorders e.g. irritable bowel syndrome, constipation, diverticulitis
✕. Current smokers
✕. Consumes more than 2 alcoholic drinks per day i.e. one drink is defined as either 150ml of wine, 340ml of beer/cider or 45ml of distilled spirit
✕. Taking lipid-lowering and blood pressure controlling medications less than 3 years

What they're measuring

Change in eczema severity using the SCORing Atopic Dermatitis (SCORAD) index

Timeframe: Every 3 weeks (Week 0, Week 3, Week 6, Week 9, Week 12)

Change in eczema severity using the Eczema Area Severity Index (EASI)

Timeframe: Every 3 weeks (Week 0, Week 3, Week 6, Week 9, Week 12)

Change in skin quality of life assessment using the Dermatology Life Quality Index (DLQI)

Timeframe: Every 3 weeks (Week 0, Week 3, Week 6, Week 9, Week 12)

Change in skin hydration level using corneometer

Timeframe: Every 3 weeks (Week 0, Week 3, Week 6, Week 9, Week 12)

Change in transepidermal water loss level using tewameter

Timeframe: Every 3 weeks (Week 0, Week 3, Week 6, Week 9, Week 12)

Change in skin pH level using pH probe

Timeframe: Every 3 weeks (Week 0, Week 3, Week 6, Week 9, Week 12)

Change in skin sebum level using sebumeter

Timeframe: Every 3 weeks (Week 0, Week 3, Week 6, Week 9, Week 12)

Trial details

NCT IDNCT05913791

SponsorNational University of Singapore

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-07-31

View on ClinicalTrials.gov More Eczema, Atopic trials

Plain-language summary

Who can participate

Age range21 Years – 59 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. English-literate and able to give informed consent in English
✓. Male and female subjects, aged between 21 and 59 inclusive
✓. Healthy individuals with no comorbidities or on regular medication
✓. BMI between 18.5-25 kg/m2
✓. Mild to moderate severity of eczema, which will also be determined using our questionnaires during screening visit

Exclusion criteria

✕. Significant change in body weight (3 kg or more) in the past 3 months
✕. Significant exercise pattern over the past 3 months defined as high-intensity exercise of more than 3 hours per week
✕. Known food allergy to eggs
✕. Taking dietary supplements which may impact the study results
✕. Had been diagnosed or with a history of gastrointestinal disorders e.g. irritable bowel syndrome, constipation, diverticulitis
✕. Current smokers
✕. Consumes more than 2 alcoholic drinks per day i.e. one drink is defined as either 150ml of wine, 340ml of beer/cider or 45ml of distilled spirit
✕. Taking lipid-lowering and blood pressure controlling medications less than 3 years

What they're measuring

Change in eczema severity using the SCORing Atopic Dermatitis (SCORAD) index

Timeframe: Every 3 weeks (Week 0, Week 3, Week 6, Week 9, Week 12)

Change in eczema severity using the Eczema Area Severity Index (EASI)

Timeframe: Every 3 weeks (Week 0, Week 3, Week 6, Week 9, Week 12)

Change in skin quality of life assessment using the Dermatology Life Quality Index (DLQI)

Timeframe: Every 3 weeks (Week 0, Week 3, Week 6, Week 9, Week 12)

Change in skin hydration level using corneometer

Timeframe: Every 3 weeks (Week 0, Week 3, Week 6, Week 9, Week 12)

Change in transepidermal water loss level using tewameter

Timeframe: Every 3 weeks (Week 0, Week 3, Week 6, Week 9, Week 12)

Change in skin pH level using pH probe

Timeframe: Every 3 weeks (Week 0, Week 3, Week 6, Week 9, Week 12)

Change in skin sebum level using sebumeter

Timeframe: Every 3 weeks (Week 0, Week 3, Week 6, Week 9, Week 12)