CompletedNot Applicable

Chemosensory Dysfunction and Recovery in Endoscopic Endonasal Skull Base Surgery

United States41 participantsStarted 2023-02-01

Plain-language summary

The investigators hypothesize that patients undergoing endoscopic endonasal skull base surgery experience clinically meaningful and modifiable disruptions in postoperative chemosensory function and quality of life, and the investigators further hypothesize that olfactory training in the postoperative period may significantly hasten normalization of patients' chemosensory perturbations. This tailored prospective study seeks to fulfill a significant gap in the understanding of the characteristics, implications, and treatment options for postoperative olfactory and gustatory impairment following endoscopic endonasal skull base surgery.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * English Speaking * preoperative diagnosis of benign sellar or parasellar skull base pathology Exclusion Criteria: * preoperative diagnosis of malignant sellar or parasellar skull base pathology * history of endoscopic sinus surgery * history of skull base surgery * history of radiation therapy or other local treatments for the management of facial, sinonasal, or cranial pathologies * history of chronic rhinosinusitis * history of neurocognitive disorder * history of intrinsic chemosensory pathology * history of cardiac pacemaker * history of gastrectomy

What they're measuring

Change in Olfactory function as assessed by the Sniffin Sticks olfactory testing kit

Timeframe: Pre-operative visit (baseline), 2 weeks post-operative, 1 month post-operative, 3 months post-operative

Trial details

NCT IDNCT05912881

SponsorJohns Hopkins University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-01-01

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