RecruitingNot Applicable

Treatment With Endovascular Intervention for STroke Patients With Existing Disability

United States1,060 participantsStarted 2023-11-16

Plain-language summary

TESTED will compare the risks and benefits of endovascular thrombectomy (EVT) to medical management (no EVT) in ischemic stroke patients who have a blockage in one of the large blood vessels in the brain and have a moderate-to-severe disability prior to their stroke.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Adult patients (≥18 years)
✓. Moderate-to-severe pre-stroke functional disability, defined as mRS 3-4, for at least 3 months prior to stroke onset
✓. Presenting to study hospital within 24 hours of last known well time
✓. Diagnosis of acute ischemic stroke
✓. Intracranial causative occlusion of the internal carotid artery or the M1 or dominant M2 segments of the middle cerebral artery visualized on the baseline CT(or MR) angiogram
✓. Presenting CT Alberta Stroke Program Early CT (ASPECT) score ≥3 or MRI ASPECT score ≥4
✓. Presenting NIH Stroke Scale score ≥6
✓. Informed consent from patient if competent or from legally authorized representative

Exclusion criteria

✕. Known diagnosis of a terminal cancer or terminal illness at the time of stroke
✕. Assessment of pre-stroke functional status cannot be performed during the hospital stay
✕. Pre-stroke disability deemed temporary in the investigator's opinion (for example, recovering from a general medical illness or traumatic bodily injury)

What they're measuring

modified Rankin Scale (mRS)

Timeframe: 90 (±14) days after treatment initiation

Trial details

NCT IDNCT05911568

SponsorUniversity of Cincinnati

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2028-01-15

Contact for this trial

Eva Mistry, MD

513-558-1291 mistryea@ucmail.uc.edu

View on ClinicalTrials.gov More Stroke trials