CompletedNot Applicable

Effect of Sevoflurane and Remimazolam on Arterial Oxygenation During One-lung Ventilation

South Korea66 participantsStarted 2023-06-29

Plain-language summary

The goal of this clinical trial is to compare the effect of sevoflurane and remimazolam on arterial oxygenation during one lung ventilation in patients undergoing video-assisted thoracoscopic surgery.

Who can participate

Age range

19 Years – 79 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients undergoing video-assisted thoracoscopic surgery * 19 years of age or older, less than 80 years old * The American Society of Anesthesiologists (ASA) classification I-Ⅲ physical status Exclusion Criteria: * Patients with known allergy to benzodiazepine, propofol * Patients with galactose intolerance, Lapp lactase deficiency, glucose-galactose malabsorption * Patients with hypersensitivity to Dextran40 * Patients with end stage renal disease requiring hemodialysis * Patients with history of acute angle glaucoma * Emergency operation * Patients with unstable hemodynamics requiring inotropics * Patients with preoperative oxygen supplement * Preoperative forced expiratory volume (FEV1) less than 40% of predicted * Preoperative ejection fraction less than 50%

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

PaO2 after 30 minutes of OLV (T2)

Timeframe: arterial blood sampling will be taken over four times: T0 (after 10 minute of TLV in lateral decubitus position), T1 (after 15 minutes of OLV), T2 (after 30 minutes of OLV), T3 (after 60 minutes of OLV)

Trial details

NCT IDNCT05907525

SponsorPusan National University Yangsan Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-04-15

View on ClinicalTrials.gov More One-Lung Ventilation trials

Who can participate

Age range

19 Years – 79 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.