The goal of this clinical study is to investigate the effectiveness of non-invasive stimulation to enhance cognitive control abilities in cognitively healthy adults and older adults diagnosed with mild cognitive disorder (MCI). The main questions it aims to answer are: * whether it is possible to restore various cognitive functions in older adults diagnosed with MCI by delivering theta burst stimulation (TBS), a form of transcranial magnetic stimulation, and * whether closed-loop TBS is able to induce therapeutic benefits that outperform open-loop TBS. Participants play a cognitive video game while a brain-computer interface (BCI) analyzes their electroencephalogram (EEG) signals and decodes the presence or absence of the contingent negative variation (CNV) potential, a marker of cognitive control. The BCI triggers TBS when its outputs indicate that the participant is not engaged properly in the video game. Researchers will compare the effects of sham, closed-loop, and open-loop TBS using the outcome metrics described below to see how much cognitive restorations is achievable with each stimulation modality.
Age range
18 Years – 90 Years
Sex
ALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Behavioral performance of the video game task
Timeframe: Up to 1 hour after intervention
Accuracy of the BCI classifier output
Timeframe: Up to 1 hour after intervention
Cognitive assessment I: Montreal Cognitive Assessment
Timeframe: Up to 8 weeks after intervention
Cognitive assessment II: Hopkins Adult Reading Test
Timeframe: Up to 8 weeks after intervention
Cognitive assessment III: Multilingual Naming Test
Timeframe: Up to 8 weeks after intervention
Cognitive assessment IV: Animal Naming
Timeframe: Up to 8 weeks after intervention
Cognitive assessment V: Number Span
Timeframe: Up to 8 weeks after intervention
Cognitive assessment VI: Trail Making Test
Timeframe: Up to 8 weeks after intervention
Cognitive assessment VII: Southwestern Assessment of Processing Speed
Timeframe: Up to 8 weeks after intervention
Cognitive assessment VIII: Hopkins Verbal Learning Test-Revised
Timeframe: Up to 8 weeks after intervention
Cognitive assessment IX: Brief Visuospatial Memory Test-Revised
Timeframe: Up to 8 weeks after intervention
Cognitive assessment X: Controlled Oral Word Association Test
Timeframe: Up to 8 weeks after intervention
Cognitive assessment XI: Stroop Color and Word Test
Timeframe: Up to 8 weeks after intervention