Ketamine Tolerated Dose for Postpartum Depression and Pain After Cesarean Delivery (PREPARE 1)

Inclusion Criteria: * Adults 18 years and older * Cesarean Delivery * American Society of Anesthesiologists Physical Status of 2 or 3 * Neuraxial anesthesia with neuraxial morphine * Term delivery ≥37 weeks gestation * Either planning not to breastfeed, OR receiving ketamine as part of routine clinical care Exclusion Criteria: * General anesthesia * Allergy to study medications * ASA PS 4 or higher * Contraindications to neuraxial anesthesia * Preterm delivery (\<37 weeks gestation) * Anticipated fetal-neonatal complex care plan * Participating in another pain intervention trial * Hypertensive disorder of pregnancy * Pre-eclampsia with severe features * Hemodynamic instability * Medical History exclusions: ketamine or PCP (phencyclidine) abuse, schizophrenia or psychosis, liver or renal insufficiency, uncontrolled hypertension, chest pain, arrhythmia, head trauma, or intracranial hypertension, uncontrolled thyroid disease, or other contraindications to ketamine