Dry Eye Symptom Mitigation by Oral Intake of Probiotics (NCT05906381) | Clinical Trial Compass
CompletedNot Applicable
Dry Eye Symptom Mitigation by Oral Intake of Probiotics
Taiwan88 participantsStarted 2023-05-13
Plain-language summary
This study investigates whether the oral intake of a probiotics capsule product may relieve dry eye symptoms. Participants will be aged between 20 - 65 years of age, with confirmed diagnosis of dry eye status. The participants will be assessed for several parameters and asked to take 1 probiotics capsule per day for 35 days. The parameters will include ocular surface health, tear volume, tear quality, intraocular pressure, tear osmolarity and serum biochemical test. After the 35 days are completed, the participants will be assessed again for the same parameters.
Who can participate
Age range
20 Years – 65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* aged between 20 and 65 years
* with Schirmer's test results less than 10 mm or Ocular Surface Disease Index more than 25
Exclusion Criteria:
* evident ocular diseases such as cornea disease, cataract, vitreous degeneration, glaucoma, and retinopathy.
* diabetes
* hypertension
* or other chronic diseases or belong to vulnerable groups(pregnancy woman, prisoner, ethical minorities, economic or educationally disadvantaged subjects, disabled individuals such as those at terminal stage of tumorigenesis, blindness, terminal ill individuals)
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial tested oral probiotics — not eye drops or medications — for dry eye symptoms, so could you help me understand whether there's any scientific reason probiotics might actually help my specific dry eye situation, based on what my tear film tests show?
2The trial measured things like Schirmer's test, tear film breakup time, and tear osmolarity — could we run these same tests on me so I have a baseline, and would those results help us judge whether a probiotic approach might even be worth trying?
3Since this was a completed trial listed as Phase NA, meaning it wasn't a standard drug trial with the usual phase-by-phase safety buildup, what do we actually know about the safety and effectiveness of taking probiotics for dry eye compared to the treatments you'd normally recommend for me?
4The trial also included serum biochemical blood testing, which suggests they were looking at systemic body changes beyond just the eyes — is there anything about my overall health or gut health that you think could be relevant to whether probiotics might help or cause any concerns for me?
5Given that this trial is already completed, is the results data available yet, and would it change your thinking about whether an oral probiotic is something worth adding to my current dry eye treatment plan?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.