RecruitingNot Applicable

Disruptions of Brain Networks and Sleep by Electroconvulsive Therapy

United States50 participantsStarted 2023-03-07

Plain-language summary

Electroconvulsive therapy (ECT) alleviates treatment-resistant depression (TRD) through repeated generalized seizures. The goal of this study is to evaluate how ECT impacts sleep-wake regulation and efficiency of information transfer in functional networks in different states of arousal.

Who can participate

Age range21 Years – 65 Years

SexALL

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Inclusion Criteria: * Referral for initial ECT index course for Treatment-Resistant Depression (TRD), unipolar major depressive disorder or bipolar depression. Historic failure of response or remission to at least two antidepressant medications of sufficient dose and duration will be used for TRD diagnostic. Exclusion Criteria: * Diagnoses of schizophrenia or schizoaffective disorders. * Subjects who are unable to tolerate the Dreem device for sleep recordings will be excluded from the study.

What they're measuring

Slow wave activity (SWA) during non-rapid eye movement sleep (NREM) stage N2/N3

Timeframe: Up to 4 weeks during patients ECT treatment course

Graph-based neural connectivity measure of local efficiency of information transfer (Elocal) during wakefulness

Timeframe: Up to 4 weeks during patients ECT treatment course

Graph-based neural connectivity measure of global information transfer (Eglobal) during ECT-induced seizure

Timeframe: Up to 4 weeks during patients ECT treatment course

Trial details

NCT IDNCT05905705

SponsorWashington University School of Medicine

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2027-07-31

Contact for this trial

Robby Greenspan

314-273-6129 greenspan@wustl.edu

View on ClinicalTrials.gov More Treatment Resistant Depression trials