CompletedNot Applicable

The Impact of Exercise on Subthalamic Nucleus Neural Activity in Parkinson's Disease

United States15 participantsStarted 2023-08-15

Plain-language summary

Fifteen PwPD who have undergone DBS surgery and utilize the Percept system will complete a FE and VE exercise session on a stationary cycle while Off antiparkinsonian medication. Bilateral neural activity of the STN will be continuously recorded for 130 minutes (pre-, during FE or VE and post-exercise). The Movement Disorders Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) III Motor Exam and upper extremity force-tracking task will be used to determine motor response to exercise.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Adult with a diagnosis of PD by a movement disorders neurologist
. Previous placement, at least six months, of bilateral Medtronic Precept DBS as standard of care treatment for their PD.
. Stable and clinically optimized DBS parameters for three months prior to enrollment.
. Demonstrate the ability to safely mount and dismount a recumbent exercise cycle with an upright back.
. Willingness to withhold antiparkinsonian medication and DBS stimulation.
. Exercise clearance using the American College of Sports Medicine (ACSM) Pre-participation Health Screen: a. If the ACSM screen recommends medical clearance, the subject must obtain medical clearance by their health care provider prior to participation; b. Those who choose not to obtain physician clearance will not be eligible for participation.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Finger Tapping

Timeframe: Pre- and Post-Exercise

Force Tracking

Timeframe: Pre- and Post-Exercise

Local Field Potential

Timeframe: Pre- and Post-Exercise

Trial details

NCT IDNCT05905302

SponsorJay Alberts

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-09-20

Results submitted2025-09-29

View on ClinicalTrials.gov More Parkinson Disease trials

Plain-language summary

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Adult with a diagnosis of PD by a movement disorders neurologist
. Previous placement, at least six months, of bilateral Medtronic Precept DBS as standard of care treatment for their PD.
. Stable and clinically optimized DBS parameters for three months prior to enrollment.
. Demonstrate the ability to safely mount and dismount a recumbent exercise cycle with an upright back.
. Willingness to withhold antiparkinsonian medication and DBS stimulation.
. Exercise clearance using the American College of Sports Medicine (ACSM) Pre-participation Health Screen: a. If the ACSM screen recommends medical clearance, the subject must obtain medical clearance by their health care provider prior to participation; b. Those who choose not to obtain physician clearance will not be eligible for participation.

The Impact of Exercise on Subthalamic Nucleus Neural Activity in Parkinson's Disease

Plain-language summary

Who can participate

Inclusion criteria

Questions worth asking your doctor

Questions for the trial coordinator

What they're measuring

Trial details

The Impact of Exercise on Subthalamic Nucleus Neural Activity in Parkinson's Disease

Plain-language summary

Who can participate

Inclusion criteria

Questions worth asking your doctor

Questions for the trial coordinator

What they're measuring

Trial details

Exclusion criteria