Magnetic Resonance Spectroscopy in Acid Sphingomyelinase Deficiency

Inclusion Criteria: Patients: * The patient has biochemically proven ASMD (preferably genetically confirmed) * The patient is willing and able to provide written informed consent prior to the study-related procedure. * The patient is ≥ 18 years of age Healthy controls: * The individual is willing and able to provide written informed consent prior to the study-related procedure * The individual is ≥ 18 years of age * General good health as determined by medical history Exclusion Criteria: Patients and healthy controls: * Inability to adhere to the study protocol * Inability to undergo an MRI procedure