Evaluation of the Efficacy of Cryotherapy Combined With Intralesional Hepatitis B Virus Vaccine Versus Either Therapy in the Treatment of Multiple Cutaneous Warts :a Comparative Study

Inclusion Criteria: * Any patients with multiple cutaneous warts of any site. * Patients age above 10 years old * No concurrent systemic or topical treatment of warts Exclusion Criteria: * Pregnancy and lactation. * History of any bleeding, clotting disorder or using anticoagulants * Chronic systemic diseases such as chronic renal failure, hepatic insufficiency, and cardiovascular disorders. * Concurrent use of systemic or topical treatments of warts. * Patients with history of neuropathy or peripheral ischemia. * Patients with signs of inflammation or infection. * Patients with history of a serious systemic or anaphylactic reaction or allergy to a prior dose of HBV vaccine or to any of its components.