The Value of Peripheral Arterial Resistive Index in Evaluation of Tissue Perfusion in Patients Wi… (NCT05902273) | Clinical Trial Compass
CompletedNot Applicable
The Value of Peripheral Arterial Resistive Index in Evaluation of Tissue Perfusion in Patients With Septic Shock
Turkey (Türkiye)50 participantsStarted 2022-04-01
Plain-language summary
In patients with septic shock, routine arterial blood pressure and central venous pressure are monitored in ICU. Conventional methods such as blood pressure and central venous pressure in septic patients cannot provide sufficient information in the follow-up due to the body's compensation mechanisms. The systemic vascular resistance index, which can be measured invasively or non-invasively with advanced hemodynamic monitoring methods, is a parameter that plays an important role in the management of septic patients.
Resistive index (Pourcelot Index) is an ultrasonic measurement method used to evaluate tissue perfusion and microcirculation. Since peripheral tissue perfusion is impaired in septic patients, the investigators think resistive index may be useful for management of sepsis. There are studies in the literature on the use of resistive index in the follow-up of patients.
The study will be about whether there is a correlation between the systemic vascular resistance index measured by cardiac output measurement, which is one of the advanced monitoring methods routinely used in the group requiring mechanical ventilation support in patients with septic shock, and the peripheral arterial resistive index, which is routinely used to evaluate tissue perfusion and microcirculation.
Who can participate
Age range
18 Years – 99 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* \>18 years old
* admitted to intensive care for septic shock
* mechanical ventilated
* non spontaneous breathing
* applied invasive artery cannulation (radial, femoral, brachial)
* applied central venous catheter (jugular, subclavian)
* SOFA score\>2
* Receiving vasopressor/inotrope support to achieve MAP ≥65 mmHg
* Blood lactate \>2mmol/L
Exclusion Criteria:
* \<18 years old
* Hypothermia (\<35C)
* Atrial fibrilation/flutter
* Pace-maker
* Severe aort valve insufficiency
* History of aortic and the great arteries adjacent to the aortic arch surgery
* Bilateral radial artery puncture in last 12 hours
* Peripheral artery disease
* Extremity amputation (leg or arm)
* Wound on forearm
* Continous Renal Replacement Therapy
* Spontaneous breath effort
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
correlation of snuffbox radial artery resistive index and systemic vascular resistance index
Timeframe: 1 hour. As soon as patient meets all of the inclusion criteria