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MRI Study of Blood-brain Barrier Function in CADASIL

China100 participantsStarted 2021-04-01

Plain-language summary

Diffusion prepared pseudo-continuous ASL (DP-pCASL) is a newly proposed MRI method to noninvasively measure the function of blood-brain barrier (BBB). The investigators aim to investigate whether the water exchange rate across the BBB, estimated with DP-pCASL, is changed in patients with CADASIL, and to analyze the association between BBB water exchange rate and MRI/clinical features in these patients.

Who can participate

Age range20 Years – 70 Years

SexALL

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Inclusion criteria

✓. Patients with CADASIL confirmed by gene or/and skin biopsy.
✓. The age range is 20-70 years old.
✓. There is no contraindication to MRI examination, and the informed consent is signed.

Exclusion criteria

✕. Combined with definite cerebrovascular disease, or combined with brain tumor, brain trauma and other causes of brain diseases.
✕. CADASIL is not confirmed.
✕. There are contraindications to examination or refusal to sign the informed consent.

What they're measuring

Timeframe: 30 Minutes

Trial details

NCT IDNCT05902039

SponsorPeking University First Hospital

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2025-04-01

Contact for this trial

Chen Ling, PhD

+86 18101358135 lnyy.chen@foxmail.com

View on ClinicalTrials.gov More Cadasil trials