WithdrawnNot Applicable

Efficacy of Zinc Supplementation on Botox Treated Forehead Rhytids

Stopped: Per the PI, the project is not IRB approved yet and will likely not be completed.

0Started 2024-08

Plain-language summary

The current literature suggests that zinc supplementation may increase the duration of botulinum toxin; however, each study had their limitations. Further, no one has studied the effect of zinc supplementation for botulinum toxin treatment of the forehead. The purpose of this study is to evaluate the effect of zinc supplementation on frontalis muscle denervation by objectively assessing the degree of forehead rhytids and movement of the eyebrows.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: Any patient older than 18 years old who desires botulinum toxin injection to decrease forehead rhytids Exclusion Criteria: * Allergy to any components of zinc citrate or botulinum toxin * inflammation or infection at site of injection * patients using anticholineresterase or other agents interfering with neuromuscular transmission * patients with any medical condition that can affect frontalis function (Bell's palsy, Möbius syndrome, Hemifacial microsomia, CHARGE syndrome, stroke, etc) * patients with any prior trauma that could have potentially injured the frontalis muscle * patients dependent on intact facial movements and expressions for their livelihood (actors, singers, musicians, etc)

What they're measuring

Duration of botulinum toxin on eyebrow excursion

Timeframe: 1 year

Duration of botulinum toxin effect on forehead rhytids

Timeframe: 1 year

Trial details

NCT IDNCT05894109

SponsorUniversity of New Mexico

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-10

View on ClinicalTrials.gov More Adjuvant Zinc May Increase the Efficacy of Botulinum Toxin trials