The investigators present a weight loss diet intervention study, to be conducted as a within-subject design, with all food and beverages provided, to assess interaction of non-nutritive sweetener (sucralose) with a high-fibre weight loss diet, on markers of gut health in humans. This study will allow assessment of the effects of a non-nutritive sweetener (sucralose) with a high-fibre (soluble fibre, fructo-oligosaccharides, FOS) diet on metabolic health and activity and composition of gut microbiota, by a controlled human diet intervention study. The investigators propose to recruit participants living with obesity, with a poor diet quality (moderate habitual fibre intake) to additionally address diet inequalities in the research approach, and this will also allow examine the time-course of adaptation of the gut microbiome (measured in faecal samples). The investigators will also assess changes in free-living glycaemic control with addition of dietary fibre and bio-markers of health.
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Change in gut metabolites (from faecal samples) in response to dietary fibre and non-nutritive sweetener
Timeframe: At baseline and end of each arm (study days 1, 15, 29 and 43)
Change in gut microbiome composition (from faecal samples) in response to dietary fibre and non-nutritive sweetener
Timeframe: At baseline and end of each arm (study days 1, 15, 29 and 43)
Change in gut metabolite production (from faecal samples) in response to dietary fibre and non-nutritive sweetener
Timeframe: At baseline and end of each arm (study days 1, 15, 29 and 43)