Nerve Block Anesthesia Combined With Sedative Anesthesia Versus General Anesthesia in Surgery for… (NCT05888389) | Clinical Trial Compass
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Nerve Block Anesthesia Combined With Sedative Anesthesia Versus General Anesthesia in Surgery for CSDH
China190 participantsStarted 2024-04-01
Plain-language summary
A prospective, multicenter, randomized controlled trial is designed to evaluate the safety of nerve block anesthesia combined with sedative anesthesia versus general anesthesia during burr hole craniostomy with drainage for chronic subdural hematoma.
Who can participate
Age range18 Years – 80 Years
SexALL
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Inclusion Criteria:
* Patients with chronic subdural hematoma with preoperative neurological dysfunction for burr hole drainage;
* Age beween 18 to 80
* Chronic subdural hematoma verified on cranial computed tomography or magnetic resonance imaging with hematoma thickness \>1.0cm or midline shift \>1.0 cm.
* Written informed consent obtained
Exclusion Criteria:
* Preoperative unconsciousness (Glasgow Coma Scale\<13, or Markwalder Grade 2-4) or cognitive dysfunction (Mini-Cog≤3, or MMSE≤20)
* Preoperative sensory or motor aphasia
* Recurrence of hematoma with previous surgery for chronic subdural hematoma.
* Previous intracranial surgery or with intracranial lesion
* with severe comorbidity or other organ dysfunction
* Allergic to anesthetics
* Severe coagulopathy or high risk of life-threatening bleeding
* Participating in another research