CompletedNot Applicable

Biomarkers for Predicting the Response to Inhaled Corticosteroid in Patients With Chronic Cough.

China502 participantsStarted 2023-04-01

Plain-language summary

To investigate the value of blood eosinophils, FeNO and total IgE in predicting the response to inhaled corticosteroid in patients with chronic cough.

Who can participate

Age range18 Years – 70 Years

SexALL

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Inclusion criteria

✓. Age: 18-70 years;
✓. Coughing lasting ≥ 8 weeks；
✓. No abnormality in chest imaging in the past 3 months (or there is abnormality but the investigator judges it not the cause of chronic cough)；
✓. FEV1% pred\>70%；FEV1/FVC\>70%；
✓. VAS≥30 in the past 48 hours;
✓. Non-smokers or patients smoked less than 10 pack-years;
✓. Candidates voluntarily participate in and abide by the relevant regulations of the study, can cooperate with corresponding inspections, follow the follow-up plan, and voluntarily sign written informed consent.

Exclusion criteria

✕. Patients received inhaled or oral corticosteroids or leukotriene receptor antagonist in previous 4 weeks;
✕. Patients with history of upper respiratory tract infection in the past 8 weeks;
✕. Patients taking angiotensin-converting enzyme inhibitors in previous 8 weeks;
✕. Female subjects who are pregnant, breast-feeding or risk of becoming pregnant during the study;
✕. Combined with a definite history of pulmonary diseases such as bronchiectasis, pulmonary interstitial disease, and pulmonary hypertension. Combined with other serious diseases (such as cardiovascular system diseases, metabolic system diseases, immune system diseases, nervous system diseases, etc.) that may affect the normal process of this study;
✕. Participating in other drug clinical trial projects.

What they're measuring

Cough VAS change from baseline to the 4th week

Timeframe: the 4th week

Trial details

NCT IDNCT05888350

SponsorThe First Affiliated Hospital of Guangzhou Medical University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-04-30

View on ClinicalTrials.gov More Cough trials