CompletedNot Applicable

Comparison of PRP & DFDBA vs. DFDBA in Intrabony Periodontal Defects

India13 participantsStarted 2012-01

Plain-language summary

The purpose of this clinical trial is to compare the results in subjects with periodontitis using subjects own blood - Platelet-rich plasma (PRP) combined with bone graft material, namely, Demineralized Freeze - Dried Bone Allograft (DFDBA) or DFDBA alone in the treatment of bone defects around the teeth.

Who can participate

Age range28 Years – 55 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Outpatients * with chronic periodontitis * who were free of local or systemic disease * who had not received any type of periodontal therapy in the last six months * radiograph showing at least one angular defect in any quadrant * the involved teeth were vital and asymptomatic * the site of interest had at least 2 mm of keratinized gingiva on the facial aspect of the selected teeth Exclusion Criteria: * Patients with abnormal platelet count * allergic to chlorhexidine or any other medicine used in the study * showing unacceptable oral hygiene compliance during / after the phase I therapy; * pregnant or lactating mothers; * smokers * endodontically involved teeth * patients under any medication known to interfere with periodontal healing. e.g., corticosteroids * on anticoagulant therapy * patients with transferable jobs or who were uncooperative * patients participating in other dental clinical trials.

What they're measuring

Change in Probing Pocket Depth (PPD) from baseline to 12 months

Timeframe: baseline to 12 months

Change in Periodontal Attachment Level (PAL) from baseline to 12 months

Timeframe: baseline to 12 months

Change in Gingival Recession (GR) from baseline to 12 months

Timeframe: baseline to 12 months

Change in Crestal bone resorption from baseline to 12 months

Timeframe: baseline to 12 months

Change in Defect fill from baseline to 12 months

Timeframe: baseline to 12 months

Change in Defect resolution from baseline to 12 months

Timeframe: baseline to 12 months

Trial details

NCT IDNCT05886699

SponsorGovernment Dental College and Hospital, India

Sponsor typeOTHER_GOV

Study typeINTERVENTIONAL

Primary completion2012-12

View on ClinicalTrials.gov More Chronic Periodontitis trials

Plain-language summary

Who can participate

Age range28 Years – 55 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Change in Probing Pocket Depth (PPD) from baseline to 12 months

Timeframe: baseline to 12 months

Change in Periodontal Attachment Level (PAL) from baseline to 12 months

Timeframe: baseline to 12 months

Change in Gingival Recession (GR) from baseline to 12 months

Timeframe: baseline to 12 months

Change in Crestal bone resorption from baseline to 12 months

Timeframe: baseline to 12 months

Change in Defect fill from baseline to 12 months

Timeframe: baseline to 12 months

Change in Defect resolution from baseline to 12 months

Timeframe: baseline to 12 months