CompletedNot Applicable

Comparison of PRP & DFDBA vs. DFDBA in Intrabony Periodontal Defects

India13 participantsStarted 2012-01

Plain-language summary

The purpose of this clinical trial is to compare the results in subjects with periodontitis using subjects own blood - Platelet-rich plasma (PRP) combined with bone graft material, namely, Demineralized Freeze - Dried Bone Allograft (DFDBA) or DFDBA alone in the treatment of bone defects around the teeth.

Who can participate

Age range

28 Years – 55 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Outpatients * with chronic periodontitis * who were free of local or systemic disease * who had not received any type of periodontal therapy in the last six months * radiograph showing at least one angular defect in any quadrant * the involved teeth were vital and asymptomatic * the site of interest had at least 2 mm of keratinized gingiva on the facial aspect of the selected teeth Exclusion Criteria: * Patients with abnormal platelet count * allergic to chlorhexidine or any other medicine used in the study * showing unacceptable oral hygiene compliance during / after the phase I therapy; * pregnant or lactating mothers; * smokers * endodontically involved teeth * patients under any medication known to interfere with periodontal healing. e.g., corticosteroids * on anticoagulant therapy * patients with transferable jobs or who were uncooperative * patients participating in other dental clinical trials.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Change in Probing Pocket Depth (PPD) from baseline to 12 months

Timeframe: baseline to 12 months

Change in Periodontal Attachment Level (PAL) from baseline to 12 months

Timeframe: baseline to 12 months

Change in Gingival Recession (GR) from baseline to 12 months

Timeframe: baseline to 12 months

Change in Crestal bone resorption from baseline to 12 months

Timeframe: baseline to 12 months

Change in Defect fill from baseline to 12 months

Timeframe: baseline to 12 months

Change in Defect resolution from baseline to 12 months

Timeframe: baseline to 12 months

Trial details

NCT IDNCT05886699

SponsorGovernment Dental College and Hospital, India

Sponsor typeOTHER_GOV

Study typeINTERVENTIONAL

Primary completion2012-12

View on ClinicalTrials.gov More Chronic Periodontitis trials

Plain-language summary

Who can participate

Age range

28 Years – 55 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Change in Probing Pocket Depth (PPD) from baseline to 12 months

Timeframe: baseline to 12 months

Change in Periodontal Attachment Level (PAL) from baseline to 12 months

Timeframe: baseline to 12 months

Change in Gingival Recession (GR) from baseline to 12 months

Timeframe: baseline to 12 months

Change in Crestal bone resorption from baseline to 12 months

Timeframe: baseline to 12 months

Change in Defect fill from baseline to 12 months

Timeframe: baseline to 12 months

Change in Defect resolution from baseline to 12 months

Timeframe: baseline to 12 months