The Plasticity of Social Brain Network in Adults With Autism Spectrum Disorder (NCT05884853) | Clinical Trial Compass
RecruitingNot Applicable
The Plasticity of Social Brain Network in Adults With Autism Spectrum Disorder
Taiwan120 participantsStarted 2021-01-01
Plain-language summary
"Social brain" refers to brain regions dedicated to processing social information and enabling us to recognize and evaluate others' mental states. The social brain hypothesis suggests that our brains evolve to navigate complex social systems. The social brain is hypothesized to consist of a distributed network including the posterior superior temporal sulcus (pSTS), the dorsal and ventral medial prefrontal cortices (dmPFC and vmPFC), ACC and posterior cingulate cortex (PCC), the amygdala, the orbital frontal cortex (OFC), and the fusiform gyrus (FG), TPJ, inferior occipital gyrus (IOG), and the insula. Each region serves distinct role while works together to support social processing, including perceiving, interpreting, and generating responses to the intentions, dispositions, and behaviors of others.
Who can participate
Age range
18 Years – 50 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* age between 18 and 50
* diagnosed with ASD from licensed mental health or medical professional based on DSM5
* have social problems
* motivated to participate in the treatment
* fluent in chinese
* caregiver also fluent in chinese and motivated to participate
* had a full-scale IQ \> 70 on WAIS-IV
* scored ≧ 26 on the caregiver-reported Autism Spectrum Quotient (AQ), indicating clinical impairment associated with ASD.
Exclusion Criteria:
* history of major mental illness, such as bipolar affective disorder, schizophrenia, psychosis, or neurological diseases
* visual impairment and/or hearing impairment
* any metal, electronic part that cannot be removed from the body, or being pregnant, which may not be able to use fMRI scan.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Autism Diagnostic Interview Revised, ADIR
Timeframe: 16 weeks
2
The Autism Diagnostic Observation Schedule, ADOS
Timeframe: 16 weeks
3
Autism Spectrum Quotient
Timeframe: 16 weeks
4
Social Responsiveness Scale, Second Edition (SRS-2)