By InvitationPhase 4

A Study of Intravenous Acetaminophen for Small Bowel Obstruction

United States18 participantsStarted 2023-10-11

Plain-language summary

The purpose of this study is to compare IV Acetaminophen for pain control to the usual care with opioids in patients admitted for small bowel obstruction.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Small bowel obstruction diagnosed by radiographic study; and * Abdominal pain on admission. * Nothing per mouth diet. * The ability to give appropriate consent or have an appropriate representative available to do so. Exclusion Criteria: * Known liver failure or cirrhosis. * Acetaminophen toxicity on admission. * Known acetaminophen allergy. * Alcohol intoxication on admission. * History of substance abuse. * Creatinine clearance \< 30 (or Creatinine level \> 2). * Liver transplant recipients. * Ileus on admission. * Admitted for surgical intervention for SBO. * Admitted for venting Gastric tube placement. * On chronic opioid therapy (defined as use of opioid on daily or near daily basis within previous 45 days (both long acting and short acting). * Presentation without abdominal pain on admission. * Already hospitalized for other reasons and develop SBO while at the hospital. * Pregnant women. * Unable to provide informed consent.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Resolution of small bowel obstruction

Timeframe: 3 days

Pain Scores

Timeframe: 3 days

Length of hospital stay

Timeframe: 3 days

Trial details

NCT IDNCT05878015

SponsorMayo Clinic

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-12

View on ClinicalTrials.gov More Small Bowel Obstruction trials

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.