CompletedNot Applicable

pBFS Guided rTMS Treating Mild Alzheimer's Disease(AD)

China46 participantsStarted 2023-09-05

Plain-language summary

This study aims to investigate the effectiveness and safety of rTMS treatment under the guidance of personalized Brain Functional Sectors (pBFS) for the cognitive ability of patients with mild Alzheimer's disease.

Who can participate

Age range

50 Years – 90 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Diagnosis of probable Alzheimer's disease (probable AD) based on the AD diagnostic criteria proposed by NIA-AA. * Positive PET or positive cerebrospinal fluid test results for beta-amyloid (Aβ). * Elementary school education or higher. * MMSE scores between 20 and 26 (including 20 and 26), or 18 and 26 for those with elementary school education. * Clinical Dementia Scale (CDR) score of 1, indicating mild dementia. * Stable medication for Alzheimer's disease for at least 3 months prior to treatment. * Availability of a reliable caregiver who can assist and accompany the patient throughout the study. * Voluntary participation with signed informed consent by the patient or legal guardian. Exclusion Criteria: * Patients who have other causes of cognitive decline apart from AD, including but not limited to vascular dementia, Parkinson's disease dementia, dementia with Lewy bodies, frontotemporal dementia, and dementia due to endocrine system lesions or deficiencies of folic acid, vitamin B12 or other causes. * Patients with significant focal lesions seen on MRI, including more than two infarct foci larger than 2 cm in diameter, infarct foci in key areas such as the thalamus, hippocampus, internal olfactory cortex, pars oligo-cortical, angular gyrus, cortical and other subcortical gray matter nuclei. * Patients with moderate to severe cerebral white matter degeneration ( Fazekas score of 3-6). * Patients unable to undergo TMS treatment or MRI scan due to me…

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1This trial used something called pBFS-guided rTMS to treat mild Alzheimer's disease — can you explain what that means in plain terms, and how it differs from the rTMS approaches that already exist for other conditions?
2The trial measured changes in ADAS-Cog scores after treatment — what would a meaningful improvement on that scale actually look like in day-to-day life for someone with mild Alzheimer's, and how does that compare to what standard treatments can offer?
3Since this trial is listed as 'Phase NA,' what does that tell us about how much is known regarding the safety and effectiveness of this approach, and should that affect how seriously we consider it as an option?
4The trial has already been completed — have the results been published or shared anywhere, and would you be able to review them with me to help us understand whether the findings are relevant to my specific situation?
5Given that this was a completed research study and not an ongoing treatment program, are there any similar trials or clinics currently offering pBFS-guided rTMS that might be worth exploring, or would standard Alzheimer's treatments be a more proven path right now?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Post-treatment ADAS-Cog change

Timeframe: Pretreatment (baseline), Post-treatment (15 days)

Trial details

NCT IDNCT05872243

SponsorChangping Laboratory

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-12-13

View on ClinicalTrials.gov More Mild Alzheimer's Disease trials

Who can participate

Age range

50 Years – 90 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.