Efficacy and Safety of Broncho Muco Cleaner Balloon Dilation Therapy

Inclusion Criteria: * Adults of both sexes aged 40-75 years * Being diagnosed with stage II-IV chronic bronchitis-predominant COPD according to the GOLD guideline * To have quit smoking for at least 6 months * mMRC 2 and above * Receiving optimal medical treatment for COPD * Being stable for at least 3 weeks * To have completed 6 weeks of pulmonary rehabilitation before the first procedure * Having sufficient mental and physical capacity to sign the voluntary consent form for the procedure. Exclusion Criteria: * be under the age of 40 and over the age of 75 * pregnant patients * breastfeeding a child * Being an active smoker * Concurrent asthma * Chronic kidney disease with GFR \<30 ml/min * Clinically significant arrhythmia, Left heart failure (EF\<45) or pulmonary hypertension (PABs\>45 mmHg) * Liver cirrhosis * Those who use anticoagulants or clopidogrel or equivalent drugs and cannot be stopped before and during the procedure, or the presence of bleeding diathesis * 6 minutes walking test \<100 meters * FEV1\<15% * Those with positive early reversibility in pulmonary function tests * Patients who do not regularly take 15lgu15in therapy for COPD * Emphysema-predominant COPD patients * Presence of active malignancy * Partial CO2 pressure \> 55mmHg or pO2\<55 mmHg in room air * Active pulmonary infection * Pneumothorax or pulmonary surgery in the last 6 months * Patients with other clinically significant lung disease other than COPD * Those who have undergone a previous l…