CompletedNot Applicable

Cannabis Observations on Brain Waves, Retrieval, and Attention: Experiment 1

United States96 participantsStarted 2022-08-17

Plain-language summary

This study investigates the impact of ∆9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on recognition memory in healthy, regular cannabis users. Participants complete the same recognition memory task after self-administering one of three different strains of cannabis flower one day and while not intoxicated another day. Event-related potentials (ERPs) are measured via electroencephalogram (EEG) during the recognition memory task. Blood is collected to quantify THC and CBD exposure. Participants also complete self-report measures of medical history, sleep quality, subjective cognitive function, physical activity, psychological functioning, substance use, and acute drug effects.

Who can participate

Age range

21 Years – 40 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Must be between the ages of 21 and 40 and provide informed consent. * Must be right-handed (Laterality Quotient \> 60 on Edinburgh Handedness Inventory - Short Form). * Must use cannabis at least 4 days during the month. * Must be a cannabis user for at least a year. * Must self-report not using other illicit recreational drugs (e.g., cocaine, benzodiazepines (non-prescription), opiates (non-prescription), MDMA, sedatives, or methamphetamine) in the past 30 days. * Must not test positive on a urine toxicology test for drugs of abuse. * Must not be using psychotropic medications, however anti-depressant, non-benzodiazepine anti-anxiety, and ADHD medications are ok. ADHD medication users must be willing to abstain from ADHD medication use on appointment days. * Must not be a regular tobacco user (≤4 days per week; cigarette, E-cigs, or smokeless). * Must not have used caffeine or tobacco (cigarette, E-cigs, or smokeless) for 4 hours prior to appointments. * Must have a breath alcohol level of 0 to sign consent form. * Must not be actively seeking or in treatment for any substance use disorder. * Female subjects must not be or trying to become pregnant. * Must not be in treatment for psychotic disorder or bipolar disorder; or have a history with these disorders. * Must not have any physical characteristics (e.g., thick hair, head size exceeding the limit of the net, dyed hair) or experience any technical difficulties during testing that result in a poor-qu…

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Difference in ERP amplitude

Timeframe: intoxicated session and not-intoxicated session

Difference in recognition memory performance

Timeframe: intoxicated session and not-intoxicated session (about 1 week)

Trial details

NCT IDNCT05868213

SponsorUniversity of Colorado, Boulder

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2024-12-15

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