Efficacy of Oral vs IV Antibiotics in the Treatment of Orofacial Osteomyelitis (NCT05867654) | Clinical Trial Compass
Not Yet RecruitingPhase 4
Efficacy of Oral vs IV Antibiotics in the Treatment of Orofacial Osteomyelitis
United States100 participantsStarted 2024-07-31
Plain-language summary
The goal of this clinical trial is compare the efficacy of oral and IV antibiotics in the treatment of orofacial osteomyelitis. The main question it aims to answer is: Are oral antibiotics as effective as IV antibiotics in the treatment of orofacial osteomyelitis.
Participants, once diagnosed with osteomyelitis, will be started on oral antibiotics for their treatment. Participants will follow up with oral and maxillofacial surgery clinic accordingly and their progression and compliance will be monitored.
Who can participate
Age range18 Years – 100 Years
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
✓. Clinical presentation of:
✓. localized pain OR
✓. localized erythema OR
✓. temperature \>38.0ºC OR
✓. a discharging sinus or wound AND
✓. willing and able to give informed consent AND
✓. aged 18 years or above AND
✓. the patient has received 7 days or less of intravenous therapy after an appropriate surgical intervention regardless of pre-surgical antibiotics
Exclusion criteria
✕. sepsis, septic shock, concomitant infection, or any need for prolonged hospitalization OR
✕. tissue diagnosis other than "dead bone" OR
✕. Staphylococcus aureus bacteremia on presentation or within a month OR
✕0. bacterial endocarditis on presentation or within the last 6 months OR
✕1. mild osteomyelitis not usually requiring prolonged IV antibiotics OR
✕2. when only IV form is available for a given antibiotic OR
✕
What they're measuring
1
Definite failure of antibiotic therapy in the treatment of orofacial osteomyelitis